How does the separation process work in GPC/SEC/FIPA?
This is more of a basic question, and Greg Stone answered this quite well in a recent webinar. So I have taken a few excerpts from his presentation to illustrate the points here. In separation science...
View ArticleThe Chromatogram Series: Hydroxylpropyl Cellulose HPC
December-2013. It is the season to be jolly. Charles Dickens once wrote “we need never be ashamed of our tears” (in his ‘Great Expectations’). This, of course, presumes that we have sufficient tears...
View ArticleThe Chromatogram Series: Polyvinylpyridine PVP
Lithium/iodine-PVP batteries were invented over 40 years ago. While the design has improved over the years, the same concept is still in reliable use in implanted pacemakers today. With clinical data...
View ArticleSeminar Series Australia – The Illumination of Structure using Light Scattering
ATA Scientific Pty Ltd, distributor of Malvern Instruments products throughout Australia, will be an active exhibitor at the upcoming Lorne Proteins Conference (9th – 13th February). An informative 1...
View ArticleWeighing heavy? It’s a matter of scale
Late in 2012 I wrote a blog post entitled “Have you got the time for Superman, dynamic light scattering, and small-angle X-ray scattering”? In this, I talked about how much bigger we are than the...
View ArticleHow to change the light scattering post-column filter membrane
When light scattering (low-angle LALS, right-angle RALS, or multi-angle MALS) is used for molecular weight detection in chromatography, the eluting mobile phase should be free of any material or...
View ArticleSize Exclusion chromatography – when to use MALS?
When is Single Angle Light Scattering (LALS/RALS) the right detection technique to use, and when do you need Multi Angle Light Scattering (MALS)? Size Exclusion Chromatography (SEC) is a...
View ArticleDo you know your polymers? We’ll show you the ropes.
I recently came back from a sailing holiday in the Caribbean. I hadn’t been sailing before but I couldn’t help but think that the ropes we used make the perfect analogy for polymers. In simplest...
View ArticleThe Fountain of Youth: Characterizing Hyaluronic Acid
As I am new to blogging I think a brief introduction would be good. My name is John Stenson, I am the Product Technical Specialist looking after the Size Exclusion Chromatography (SEC) related detector...
View ArticleMulti Angle Light Scattering (MALS)
What is multi angle light scattering MALS / MALLS? Light scattering is the effect of light being re-radiated from a sample containing molecules or particles. This scattering depends on the optical...
View ArticleFAQ: Molecular weight estimate from DLS?
Here is a question I recently encountered that I thought might be worthwhile to post here: “I would like to use the particle size data to calculate an estimate for molecule weight. Would you please...
View ArticlePolydispersity – what does it mean for DLS and chromatography?
The term polydispersity (or more recently dispersity without the poly, as per IUPAC recommendation) is used to describe the degree of “non-uniformity” of a distribution. In the field of...
View ArticleWhat’s better, a high molecular weight or high intrinsic viscosity present?
As Christmas is getting ever closer, thoughts turn to gift giving and receiving. As the product manager for our Viscotek range, I can’t help but think in scientific terms when assessing what kind of...
View ArticleOMNISEC – Your Questions Answered
Thanks so much to those of you who joined us for the launch of OMNISEC, our new GPC/SEC system. If you missed the event you can play it back by clicking here, to see how the new instrument can really...
View ArticleOMNISEC goes to SCM-7
Hello everyone! This is my first blog so I think I should start by introducing myself. My name is Amy Durrell and I am the Applications Scientist for the separation products here at Malvern...
View ArticlePerfecting Polymer Measurements: OMNISEC Q&A
A couple of weeks ago I had the opportunity to present a live webinar through Chemical & Engineering News about how our latest solution for Gel Permeation Chromatography/Size Exclusion...
View ArticleDelving deeper into protein samples using multi-detection
We recently published a new application note on protein characterization using our latest SEC system, OMNISEC, and I wanted to bring your attention to this elegant piece of work that beautifully shows...
View Article10 reasons why polymer scientists need multi-detector GPC
When we are talking to customers about advanced Gel Permeation Chromatography (GPC) systems, we can explain why ours are the best on the market or how their excellent sensitivities means you can...
View ArticleKey protein features in the Zetasizer software
The Zetasizer has some optional advanced protein features that you may not be aware of: DLS Debye Plot: a dynamic Debye plot of the measured hydrodynamic size as a function of sample concentration to...
View ArticleCharacterizing Hyaluronic Acid : The Fountain of Youth
Hyaluronic Acid Analysis As I am new to blogging I think a brief introduction would be good. My name is John Stenson, I am the Product Technical Specialist looking after the Size Exclusion...
View Article
